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Dermatol Surg. 2012 Apr;38(4):610-22. doi: 10.1111/j.1524-4725.2011.02298.x. Epub 2012 Jan 23.

Periorbital rejuvenation with fractional 1,550-nm ytterbium/erbium fiber laser and variable square pulse 2,940-nm erbium:YAG laser in Asians: a comparison study.

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Department of Medicine, Faculty of Medicine, Division of Dermatology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.



Ablative and fractional lasers are used for periorbital rejuvenation, with different downtime, side effects, and efficacy.


To compare effects of fractional 1,550-nm ytterbium- and erbium-doped (Yb/Er) fiber laser and variable square pulse (VSP) 2,940-nm erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment for periorbital wrinkles.


This side-by-side comparison study randomized 22 women with mild to moderate periorbital rhytides to receive three treatments with fractional 1,550-nm Yb/Er fiber laser or 2,940-nm Er:YAG laser treatment on either side at 4-week intervals. A video camera was used for objective assessment of wrinkles. Standardized photographs, patient satisfaction, side effects, and pain score were recorded.


Twenty subjects completed the study. The median change in wrinkle measurement 3 months after laser treatments from baseline of the fractional Yb/Er fiber laser side was -3.03 versus -3.09 on the VSP Er:YAG side (p = .63, Wilcoxon signed-rank test). There was no significant difference in degree of wrinkle improvement analyzed according to global assessment between the sides (p = .25, Wilcoxon signed-rank test). Less downtime correlated with greater patient satisfaction of the fractional laser treatment . Two subjects experienced hyperpigmentation.


Fractional Yb/Er fiber and VSP Er:YAG lasers are effective in improving periorbital wrinkles in Asians, with minimal side effects.

[Indexed for MEDLINE]

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