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Nat Neurosci. 2012 Jan 22;15(3):370-2. doi: 10.1038/nn.3035.

Thalamic control of cortical states.

Author information

1
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Abstract

We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.

PMID:
22267163
DOI:
10.1038/nn.3035
[Indexed for MEDLINE]

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