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Oncogene. 2012 Nov 8;31(45):4733-9. doi: 10.1038/onc.2011.639. Epub 2012 Jan 23.

P53-induced protein with a death domain (PIDD): master of puppets?

Author information

1
Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

Abstract

P53-induced protein with a death domain (PIDD) has been described as primary p53 target gene, induced upon DNA damage. More than 10 years after its discovery, its physiological role in the DNA damage response remains enigmatic, as it seems to be able to execute life-death decisions in vitro, yet genetic ablation in mice failed to reveal an obvious phenotype. Nonetheless, evidence is accumulating that it contributes to the fine-tuning of the DNA-damage response by orchestrating critical processes such as caspase activation or nuclear factor κB translocation and can also exert additional nuclear functions, for example, the modulation of translesion synthesis. In this review, we aim to integrate these observations and propose possible unexplored functions of PIDD.

PMID:
22266869
PMCID:
PMC4562363
DOI:
10.1038/onc.2011.639
[Indexed for MEDLINE]
Free PMC Article

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