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Nat Rev Microbiol. 2012 Jan 23;10(3):165-77. doi: 10.1038/nrmicro2673.

Structural insights into the coupling of virion assembly and rotavirus replication.

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1
Rotavirus Molecular Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Erratum in

  • Nat Rev Microbiol. 2014 Jan;12(1):70.

Abstract

Viral replication is rapid and robust, but it is far from a chaotic process. Instead, successful production of infectious progeny requires that events occur in the correct place and at the correct time. Rotaviruses (segmented double-stranded RNA viruses of the Reoviridae family) seem to govern their replication through ordered disassembly and assembly of a triple-layered icosahedral capsid. In recent years, high-resolution structural data have provided unprecedented insight into these events. In this Review, we explore the current understanding of rotavirus replication and how it compares to replication of other Reoviridae family members.

PMID:
22266782
PMCID:
PMC3771686
DOI:
10.1038/nrmicro2673
[Indexed for MEDLINE]
Free PMC Article
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