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Acta Pharmacol Sin. 2012 Mar;33(3):291-9. doi: 10.1038/aps.2011.171. Epub 2012 Jan 23.

Structure and activation of rhodopsin.

Author information

1
Laboratory of Structural Sciences, Van Andel Research Institute, NE, Grand Rapids, MI 49503, USA. edward.zhou@vai.org

Abstract

Rhodopsin is the first G-protein-coupled receptor (GPCR) with its three-dimensional structure solved by X-ray crystallography. The crystal structure of rhodopsin has revealed the molecular mechanism of photoreception and signal transduction in the visual system. Although several other GPCR crystal structures have been reported over the past few years, the rhodopsin structure remains an important model for understanding the structural and functional characteristics of other GPCRs. This review summarizes the structural features, the photoactivation, and the G protein signal transduction of rhodopsin.

PMID:
22266727
PMCID:
PMC3677203
DOI:
10.1038/aps.2011.171
[Indexed for MEDLINE]
Free PMC Article

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