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Drug Discov Today. 2012 Jun;17(11-12):544-8. doi: 10.1016/j.drudis.2012.01.002. Epub 2012 Jan 16.

The therapeutic and diagnostic potential of FKBPL; a novel anticancer protein.

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School of Pharmacy, Queen's University Belfast, UK.


The immunophilin family of proteins has a vast number of roles regulating a variety of biological processes through protein-protein interactions. A relatively new and divergent member of this family, FK506-binding protein like (FKBPL), is emerging as a key player in the DNA damage response, steroid receptor signalling and more recently, control of tumour growth where it regulates response to endocrine therapy in addition to acting as a novel antiangiogenic protein. As a new therapeutic peptide based on FKBPL approaches clinical trials, this article highlights a unique approach to targeting tumours that are resistant to current antiangiogenic therapies and supports the role of FKBPL as a novel prognostic and predictive biomarker, distinct from its other family members.

[Indexed for MEDLINE]

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