Format

Send to

Choose Destination
Physiotherapy. 2012 Mar;98(1):57-63. doi: 10.1016/j.physio.2011.01.009.

Effect of lidocaine phonophoresis on sensory blockade: pulsed or continuous mode of therapeutic ultrasound?

Author information

1
Department of Physical Therapy, School of Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran. ebrahimis@sums.ac.ir

Abstract

OBJECTIVE:

The optimisation of drug absorption through skin is of great value in modern therapy. Phonophoresis is the use of therapeutic ultrasound to increase percutaneous drug absorption. However, few studies have compared pulsed and continuous modes of therapeutic ultrasound. This study compared these two modes by investigating the effect of lidocaine phonophoresis on sensory blockade. Lidocaine is a common local anaesthetic drug that is used topically to relieve pain and also for minor surgery.

DESIGN:

Pre-post intervention study.

PARTICIPANTS:

Ninety-three healthy volunteers, assigned at random to one of three ultrasound groups: pulsed (ultrasound+lidocaine), continuous (ultrasound+lidocaine) and control (sham ultrasound+lidocaine).

INTERVENTION:

Lidocaine (approximately 2 cm3) was administered transdermally using a transducer.

OUTCOME MEASURES:

Two-point discrimination, touch and maximum pain thresholds were assessed before and after the intervention in each group.

RESULTS:

There were significant increases in two-point discrimination, touch and maximum pain thresholds after the intervention in all groups (P<0.05). The mean differences in the threshold changes between the pulsed and continuous groups were significant [two-point discrimination: mean difference 0.66 (standard deviation, SD 0.41) mm, 95% confidence interval (CI) 0.18 to 1.21, P<0.001; touch: mean difference 1.31 (SD 0.23) mA, 95% CI 0.98 to 1.96, P<0.001; maximum pain: mean difference 5.59 (SD 4.01) mA, 95% CI 1.01 to 10.11, P<0.001]. Statistical analysis also revealed significant differences for all senses between the pulsed and control groups [two-point discrimination: mean difference 0.61 (SD 0.29) mm, 95% CI 0.26 to 1.3, P<0.001; touch: mean difference 1.45 (SD 0.38) mA, 95% CI 0.96 to 2.1, P<0.001; maximum pain difference 9.17 (SD 4.13) mA, 95% CI 4.32 to 14.1, P<0.001]. The mean difference in the change in maximum pain threshold between the continuous and control groups was significant [mean difference 3.58 (SD 3.44) mA, 95% CI 0.09 to 8.3, P=0.001], but two-point discrimination and touch threshold changes revealed no significant difference between the continuous and control groups [two-point discrimination: mean difference 0.05 (SD 0.28) mm, 95% CI -0.31 to 0.48, P=0.968; touch: mean difference 0.14 (SD 0.19) mA, 95% CI -0.21 to 0.43, P=0.339].

CONCLUSION:

Pulsed ultrasound with topical lidocaine gel induced greater anaesthetic effect compared with continuous ultrasound with topical lidocaine gel and lidocaine application alone. The mechanical properties of pulsed ultrasound appear to be responsible for greater drug penetration.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01404468.

PMID:
22265386
DOI:
10.1016/j.physio.2011.01.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center