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Lancet Neurol. 2012 Feb;11(2):189-200. doi: 10.1016/S1474-4422(11)70286-1.

Non-coding RNAs with essential roles in neurodegenerative disorders.

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Centre for Human Genetics and Leuven Institute for Neurodegenerative Disorders (LIND), University of Leuven, Leuven, Belgium.


The importance of various classes of regulatory non-protein-coding RNA molecules (ncRNAs) in the normal functioning of the CNS is becoming increasingly evident. ncRNAs are involved in neuronal cell specification and patterning during development, but also in higher cognitive processes, such as structural plasticity and memory formation in the adult brain. We discuss advances in understanding of the function of ncRNAs in the CNS, with a focus on the potential involvement of specific species, such as microRNAs, endogenous small interfering RNAs, long intergenic non-coding RNAs, and natural antisense transcripts, in various neurodegenerative disorders. This emerging field is anticipated to profoundly affect clinical research, diagnosis, and therapy in neurology.

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