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Am J Intellect Dev Disabil. 2012 Jan;117(1):1-17. doi: 10.1352/1944-7558-117.1.1.

Behavioral phenotype of fragile X syndrome in adolescence and adulthood.

Author information

1
University of Wisconsin-Madison, Waisman Center, 1500 Highland Ave., Madison, WI 53705, USA. lsmith@waismnan.wisc.edu

Abstract

The present study explored the behavioral profile of individuals with fragile X syndrome during adolescence and adulthood. Individuals with both fragile X syndrome and autism (n  =  30) were compared with (a) individuals diagnosed with fragile X syndrome (but not autism; n  =  106) and (b) individuals diagnosed with autism (but not fragile X syndrome; n  =  135) on measures of autism symptoms, adaptive functioning, behavior problems, and psychological symptoms. Results indicated that individuals dually diagnosed with fragile X syndrome and autism displayed greater communication and social reciprocity impairments than individuals with fragile X syndrome only. Individuals in the dually diagnosed group also exhibited higher levels of repetitive and challenging behaviors than either comparison group, suggesting a unique profile of vulnerability for those diagnosed with both fragile X syndrome and autism.

PMID:
22264109
PMCID:
PMC3388941
DOI:
10.1352/1944-7558-117.1.1
[Indexed for MEDLINE]
Free PMC Article

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