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Free Radic Res. 2012 May;46(5):612-8. doi: 10.3109/10715762.2012.659247. Epub 2012 Feb 14.

Selective ozone concentrations may reduce the ischemic damage after a stroke.

Author information

1
Dipartimento di Neuroscienze, Sezione di Farmacologia, Universit à degli Studi di Siena, Italy.

Abstract

Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.

PMID:
22263539
DOI:
10.3109/10715762.2012.659247
[Indexed for MEDLINE]

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