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J Thorac Dis. 2009 Dec;1(1):51-4.

How to calculate sample size in randomized controlled trial?

Author information

1
Affiliated Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology.

Abstract

To design clinical trials, efficiency, ethics, cost effectively, research duration and sample size calculations are the key things to remember. This review highlights the statistical issues to estimate the sample size requirement. It elaborates the theory, methods and steps for the sample size calculation in randomized controlled trials. It also emphasizes that researchers should consider the study design first and then choose appropriate sample size calculation method.

KEYWORDS:

Randomized Controlled Trial; Sample Size Calculation

PMID:
22263004
PMCID:
PMC3256489

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