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Arthritis Care Res (Hoboken). 2012 Jun;64(6):919-24. doi: 10.1002/acr.21616. Epub 2012 Jan 19.

Prevalence and factors associated with uveitis in spondylarthritis patients in France: results from an observational survey.

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1
Université Paris Est Créteil and APHP, Hôpital Henri-Mondor, Créteil, France.

Abstract

OBJECTIVE:

To accurately estimate the prevalence of and the factors associated with uveitis in spondylarthritis (SpA) patients in France.

METHODS:

In an observational survey of SpA patients (diagnosis confirmed by the European Spondylarthropathy Study Group and/or Amor's criteria) consulting their rheumatologist for routine followup, we collected information regarding present/past history of uveitis, as well as detailed characteristics of the disease. Factors independently associated with uveitis were determined.

RESULTS:

From September 2008 to January 2009, 202 rheumatologists participated in the survey and recruited 902 patients (61% men) with a mean ± SD age of 45.3 ± 13.4 years and a mean ± SD disease duration of 10.4 ± 9.6 years. The SpA diagnoses were ankylosing spondylitis (71%), psoriatic arthritis (18%), or other SpA (11%). The HLA-B27 positivity rate was 76%. Uveitis prevalence was 32.2% (95% confidence interval [95% CI] 29.1-35.3%) since psoriasis and inflammatory bowel disease were 22.3% (95% CI 19.5-25.0%) and 8.6% (95% CI 6.7-10.5%), respectively. Recurrence of uveitis occurred in 52.3% and complications occurred in 11.7% of patients. Factors independently associated with uveitis were HLA-B27 positivity (adjusted odds ratio [OR(adj) ] 2.97 [95% CI 1.83-4.81], P < 0.0001) and disease duration (OR(adj) 1.28 [95% CI 1.16-1.41], P < 0.0001 for ≥10 years).

CONCLUSION:

Results indicate that uveitis is the most common extraarticular feature of SpA, occurring preferentially in HLA-B27-positive patients over the entire course of the disease.

PMID:
22262475
DOI:
10.1002/acr.21616
[Indexed for MEDLINE]
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