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J Cell Physiol. 2012 Sep;227(9):3169-77. doi: 10.1002/jcp.24054.

Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression.

Author information

1
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

Diet and energy metabolism affect gene expression, which influences human health and disease. Here, we discuss the role of epigenetics as a mechanistic link between energy metabolism and control of gene expression. A number of key energy metabolites including SAM, acetyl-CoA, NAD(+), and ATP serve as essential co-factors for many, perhaps most, epigenetic enzymes that regulate DNA methylation, posttranslational histone modifications, and nucleosome position. The relative abundance of these energy metabolites allows a cell to sense its energetic state. And as co-factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate/downregulate transcription as appropriate to maintain homeostasis.

PMID:
22261928
PMCID:
PMC3338882
DOI:
10.1002/jcp.24054
[Indexed for MEDLINE]
Free PMC Article

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