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J Perinatol. 2012 Oct;32(10):770-6. doi: 10.1038/jp.2011.194. Epub 2012 Jan 19.

Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome.

Author information

1
Department of Obstetrics and Gynecology, Kaiser Permanente Oakland Medical Center, Oakland, CA 94612, USA.

Abstract

OBJECTIVE:

To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).

STUDY DESIGN:

Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.

RESULT:

Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.

CONCLUSION:

A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.

PMID:
22261835
PMCID:
PMC3570271
DOI:
10.1038/jp.2011.194
[Indexed for MEDLINE]
Free PMC Article

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