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Neurodegener Dis. 2012;10(1-4):320-3. doi: 10.1159/000333811. Epub 2012 Jan 17.

Plasma β-amyloid levels in cerebral amyloid angiopathy-associated hemorrhagic stroke.

Author information

1
Neurovascular Research Laboratory, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Abstract

BACKGROUND:

Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly.

OBJECTIVE:

To analyze β-amyloid (Aβ) species in plasma in order to uncover biological markers that may contribute to improve the diagnosis of CAA in life.

METHODS:

We determined the level of Aβ(1-40), Aβ(N-40), Aβ(1-42) and Aβ(N-42) in plasma of CAA-related ICH patients (n = 29) and healthy controls (n = 21) using xMAP® technology. Hemorrhages were identified and classified using a CT scan and brain MRI. Patients were clinically classified as probable or possible CAA according to the Boston criteria.

RESULTS:

We found that plasma full-length Aβ(1-42) and truncated fragments Aβ(N-42) were higher in probable CAA patients than in controls (p < 0.001 and p = 0.046, respectively), and full-length Aβ(1-40) was selectively elevated in probable CAA compared to possible cases (p = 0.015) and controls (p = 0.005). In addition, plasma Aβ(N-42) levels were also higher in patients that presented multiple lobar macrohemorrhages compared to patients that had one symptomatic hemorrhagic event (p = 0.022), indicating that a certain degree of CAA severity is necessary to show increased Aβ fragments in peripheral circulation.

CONCLUSION:

Our results suggest that specific Aβ fragments in plasma might be considered as potential biomarkers for the diagnosis of CAA.

PMID:
22261638
DOI:
10.1159/000333811
[Indexed for MEDLINE]

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