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Neurodegener Dis. 2012;10(1-4):320-3. doi: 10.1159/000333811. Epub 2012 Jan 17.

Plasma β-amyloid levels in cerebral amyloid angiopathy-associated hemorrhagic stroke.

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Neurovascular Research Laboratory, Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.



Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly.


To analyze β-amyloid (Aβ) species in plasma in order to uncover biological markers that may contribute to improve the diagnosis of CAA in life.


We determined the level of Aβ(1-40), Aβ(N-40), Aβ(1-42) and Aβ(N-42) in plasma of CAA-related ICH patients (n = 29) and healthy controls (n = 21) using xMAP® technology. Hemorrhages were identified and classified using a CT scan and brain MRI. Patients were clinically classified as probable or possible CAA according to the Boston criteria.


We found that plasma full-length Aβ(1-42) and truncated fragments Aβ(N-42) were higher in probable CAA patients than in controls (p < 0.001 and p = 0.046, respectively), and full-length Aβ(1-40) was selectively elevated in probable CAA compared to possible cases (p = 0.015) and controls (p = 0.005). In addition, plasma Aβ(N-42) levels were also higher in patients that presented multiple lobar macrohemorrhages compared to patients that had one symptomatic hemorrhagic event (p = 0.022), indicating that a certain degree of CAA severity is necessary to show increased Aβ fragments in peripheral circulation.


Our results suggest that specific Aβ fragments in plasma might be considered as potential biomarkers for the diagnosis of CAA.

[Indexed for MEDLINE]

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