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FEBS J. 2012 Apr;279(8):1366-74. doi: 10.1111/j.1742-4658.2012.08500.x. Epub 2012 Mar 27.

The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.

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St Vincent's Centre for Applied Medical Research, Sydney, University of New South Wales, Sydney, Australia.


This brief review will first consider HIV associated neurocognitive disorder followed by the current understanding of its neuropathogenesis. Against this background the role of the kynurenine pathway will be detailed. Evidence both direct and indirect will be discussed for involvement of the kynurenine pathway at each step in the neuropathogenesis of HIV associated neurocognitive disorder.

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