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RNA Biol. 2012 Feb;9(2):137-42. doi: 10.4161/rna.18827. Epub 2012 Feb 1.

Liver-specific microRNA-122: Biogenesis and function.

Author information

1
Centre for Biomolecular Sciences; University of Nottingham; University Park; Nottingham, UK. Catherine.jopling@nottingham.ac.uk

Abstract

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.

PMID:
22258222
PMCID:
PMC3346312
DOI:
10.4161/rna.18827
[Indexed for MEDLINE]
Free PMC Article
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