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Nat Rev Cancer. 2012 Jan 19;12(2):121-32. doi: 10.1038/nrc3204.

The diverse and complex roles of NF-κB subunits in cancer.

Author information

1
Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Catherine Cookson Building, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK. neil.perkins@ncl.ac.uk

Abstract

It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-κB activation, it is now becoming clear that the inhibitor of NF-κB kinases (IKKs), which regulate NF-κB activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-κB subunits.

PMID:
22257950
DOI:
10.1038/nrc3204
[Indexed for MEDLINE]

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