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Bioorg Med Chem Lett. 2012 Feb 15;22(4):1709-11. doi: 10.1016/j.bmcl.2011.12.103. Epub 2011 Dec 30.

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Author information

1
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.

Abstract

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigated for their ability to bind with the pre-miRNA target (hsa-mir-155) and thereby to interfere with the Dicer catalyzed miRNA processing. Potential binding and inhibition effects have been demonstrated by some of these analogs. They can be used as leads for further development of potent small molecular miRNA-antagonists.

PMID:
22257890
DOI:
10.1016/j.bmcl.2011.12.103
[Indexed for MEDLINE]

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