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Exp Mol Med. 2012 Feb 29;44(2):99-108. doi: 10.3858/emm.2012.44.2.032.

Autophagy and bacterial infectious diseases.

Author information

1
Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301-747, Korea.

Abstract

Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested that autophagy can function as an intracellular innate defense pathway in response to infection with a variety of bacteria and viruses. Autophagy plays a role as a specialized immunologic effector and regulates innate immunity to exert antimicrobial defense mechanisms. Numerous bacterial pathogens have developed the ability to invade host cells or to subvert host autophagy to establish a persistent infection. In this review, we have summarized the recent advances in our understanding of the interaction between antibacterial autophagy (xenophagy) and different bacterial pathogens.

PMID:
22257885
PMCID:
PMC3296818
DOI:
10.3858/emm.2012.44.2.032
[Indexed for MEDLINE]
Free PMC Article

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