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Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3024-30. doi: 10.1109/IEMBS.2011.6090828.

Developing implantable neuroprosthetics: a new model in pig.

Author information

1
School of Engineering, Brown University, Providence, RI 02912, USA. david borton@brown.edu

Abstract

A new model has been established in the domestic pig for neural prosthetic device development and testing. To this end, we report on a complete neural prosthetic developmental system using a wireless sensor as the implant, a pig as the animal model, and a novel data acquisition paradigm for actuator control. A new type of stereotactic frame with clinically-inspired fixations pins that place the pig brain in standard surgical plane was developed and tested with success during the implantation of the microsystem. The microsystem implanted was an ultra-low power (12.5 mW) 16-channel intracortical/epicranial device transmitting broadband (40 kS/s) data over a wireless infrared telemetric link. Pigs were implanted and neural data was collected over a period of 5 weeks, clearly showing single unit spiking activity.

PMID:
22254977
PMCID:
PMC3902772
DOI:
10.1109/IEMBS.2011.6090828
[Indexed for MEDLINE]
Free PMC Article
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