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Biomed Opt Express. 2012 Jan 1;3(1):26-36. doi: 10.1364/BOE.3.000026. Epub 2011 Dec 2.

Perturbative forward solver software for small localized fluorophores in tissue.

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1
Dipartimento di Fisica e Astronomia dell’Universit`a degli Studi di Firenze,Via G. Sansone 1, 50019 Sesto Fiorentino, Firenze, Italy. fabrizio.martelli@unifi.it

Abstract

In this paper a forward solver software for the time domain and the CW domain based on the Born approximation for simulating the effect of small localized fluorophores embedded in a non-fluorescent biological tissue is proposed. The fluorescence emission is treated with a mathematical model that describes the migration of photons from the source to the fluorophore and of emitted fluorescent photons from the fluorophore to the detector for all those geometries for which Green's functions are available. Subroutines written in FORTRAN that can be used for calculating the fluorescent signal for the infinite medium and for the slab are provided with a linked file. With these subroutines, quantities such as reflectance, transmittance, and fluence rate can be calculated.

KEYWORDS:

(170.3660) Light propagation in tissues; (170.3880) Medical and biological imaging; (170.5280) Photon migration; (170.6280) Spectroscopy, fluorescence and luminescence

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