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Nutrients. 2010 Feb;2(2):128-70. doi: 10.3390/nu2020128. Epub 2010 Feb 9.

Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan.

Author information

1
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide 5000, Australia. natalie.sinn@unisa.edu.au

Abstract

Around one in four people suffer from mental illness at some stage in their lifetime. There is increasing awareness of the importance of nutrition, particularly omega-3 polyunsaturated fatty acids (n-3 PUFA), for optimal brain development and function. Hence in recent decades, researchers have explored effects of n-3 PUFA on mental health problems over the lifespan, from developmental disorders in childhood, to depression, aggression, and schizophrenia in adulthood, and cognitive decline, dementia and Alzheimer's disease in late adulthood. This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues.

KEYWORDS:

aggression; attention deficit hyperactivity disorder; autism; dementia ; depression; mental health; omega-3 polyunsaturated fatty acids

PMID:
22254013
PMCID:
PMC3257637
DOI:
10.3390/nu2020128
[Indexed for MEDLINE]
Free PMC Article
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