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Nutrients. 2009 Jan;1(1):50-70. doi: 10.3390/nu1010050. Epub 2009 Aug 14.

Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice.

Author information

1
Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA.

Abstract

Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.

KEYWORDS:

aging; dairy; dietary calcium; inflammatory stress; lifespan; oxidative stress

PMID:
22253967
PMCID:
PMC3257586
DOI:
10.3390/nu1010050
[Indexed for MEDLINE]
Free PMC Article
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