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Eur J Pharm Sci. 2012 Apr 11;45(5):639-47. doi: 10.1016/j.ejps.2012.01.003. Epub 2012 Jan 11.

Inclusion of celecoxib into fibrous ordered mesoporous carbon for enhanced oral bioavailability and reduced gastric irritancy.

Author information

1
Department of Pharmaceutics, Shenyang Pharmaceutical University, PO Box 23, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, PR China.

Abstract

Fibrous ordered mesoporous carbon (FOMC) was developed as a new drug delivery system for loading an insoluble drug, designed to be orally administered, and then to enhance the drug loading capacity, improve the dissolution rate, enhance the oral bioavailability and reduce the gastric damage. Celecoxib (CEL) was chosen as a model drug. The nanostructures and effect of different pore sizes (4.4-7.0 nm) on drug loading and release properties were studied. The results showed that FOMC has a high drug loading capacity (0.599 g/g, drug weight/carrier weight) and the dissolution rate of CEL from FOMC was much faster than pure crystalline CEL using buffer (pH 6.8) as a dissolution medium. Moreover, the oral bioavailability of CEL loaded into FOMC was significantly improved compared with that of CEL capsules and the gastric damage caused by CEL which was loaded in FOMC was also reduced, demonstrating the protective effect of FOMC.

PMID:
22251657
DOI:
10.1016/j.ejps.2012.01.003
[Indexed for MEDLINE]

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