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Arch Dermatol. 2012 May;148(5):577-84. doi: 10.1001/archdermatol.2011.2522.

Prediction of sentinel lymph node positivity by growth rate of cutaneous melanoma.

Author information

1
Servicio de Dermatología, Hospital Virgen de la Victoria, Málaga, Spain. antoniotejera@aedv.es

Abstract

OBJECTIVE:

To determine whether growth rate (GR) of cutaneous melanoma predicts the histological sentinel lymph node (SLN) positivity.

DESIGN:

Retrospective cohort study.

SETTING:

Two tertiary melanoma referral centers.

PATIENTS:

A total of 698 patients with invasive primary cutaneous melanoma in whom the SLN was identified between January 1, 2000, and June 30, 2010.

MAIN OUTCOME MEASURE:

Based on previous studies, a surrogate measure for GR in primary invasive melanoma was calculated as the ratio of Breslow thickness to time to melanoma development.

RESULTS:

The SLN was positive in 20.2% of patients. Multivariate logistic regression analysis revealed that GR, Breslow thickness, and the presence of microscopic satellitosis were independently associated with SLN positivity. The probability of SLN positivity was 8.2% for slow-growth melanomas (<0.10 mm/mo) compared with 19.8% for intermediate-growth melanomas (0.10-0.50 mm/mo) and 37.7% for fast-growth melanomas (>0.50 mm/mo). Growth rate was not an independent predictive factor for survival.

CONCLUSION:

Growth rate of primary cutaneous melanoma, together with Breslow thickness and the presence of microscopic satellitosis, predicts the histological SLN positivity.

PMID:
22250187
DOI:
10.1001/archdermatol.2011.2522
[Indexed for MEDLINE]

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