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Anal Bioanal Chem. 2012 Feb;402(6):1993-2013. doi: 10.1007/s00216-011-5630-y. Epub 2012 Jan 17.

Comprehensive two-dimensional gas chromatography in metabolomics.

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1
Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.

Abstract

One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC × GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC × GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.

PMID:
22249417
DOI:
10.1007/s00216-011-5630-y
[Indexed for MEDLINE]
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