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Cell Mol Life Sci. 2012 Jul;69(13):2125-34. doi: 10.1007/s00018-011-0916-y. Epub 2012 Jan 17.

Transcriptional control of glutamatergic differentiation during adult neurogenesis.

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1
Department of Neurological Surgery, University of Washington, Seattle, WA, USA.

Abstract

Neurogenesis, the production of new neurons, occurs in two specialized niches in the adult brain, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. In the SGZ, neural stem cells (NSCs) give rise to glutamatergic granule neurons that integrate into the granule cell layer. In the SVZ, NSCs generate a more diverse cohort of new neurons, including GABAergic, dopaminergic, and glutamatergic neurons, all of which migrate to the olfactory bulb through the rostral migratory stream. In both adult neurogenic niches, specific transcription factors have been shown to direct fate specification and lineage commitment. This review summarizes current progress on the transcriptional control of glutamatergic neurogenesis in the SGZ and SVZ, highlighting commonalities as well as differences in their transcriptional programs. In particular, we focus on work from our laboratory and others indicating that precise, sequential expression of transcription factors regulates the progression from NSC to lineage-committed progenitor, and ultimately regulates the production and differentiation of adult-born glutamatergic neurons.

PMID:
22249196
PMCID:
PMC3360923
DOI:
10.1007/s00018-011-0916-y
[Indexed for MEDLINE]
Free PMC Article
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