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Bioorg Med Chem Lett. 2012 Feb 15;22(4):1731-3. doi: 10.1016/j.bmcl.2011.12.093. Epub 2011 Dec 28.

Hybrid liposomes affect cellular lipid constituents and caveolae structures.

Author information

1
Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Abstract

We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

PMID:
22248855
DOI:
10.1016/j.bmcl.2011.12.093
[Indexed for MEDLINE]

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