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BMC Pediatr. 2012 Jan 16;12:6. doi: 10.1186/1471-2431-12-6.

Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants.

Author information

1
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas 77030, USA. sabrams@bcm.edu

Abstract

BACKGROUND:

To evaluate the effects on serum 25(OH)D and bone mineralization of supplementation of breast-fed Hispanic and non-Hispanic Caucasian infants with vitamin D in infants in Houston, Texas.

METHODS:

We measured cord serum 25(OH)D levels, bone mineral content (BMC), bone mineral density (BMD) and their changes over 3 months of life with 400 IU/day of vitamin D3 supplementation.

RESULTS:

Cord serum 25(OH)D was significantly lower in Hispanic than non-Hispanic Caucasian infants (16.4 ± 6.5 ng/mL, n = 27, vs 22.3 ± 9.4 n = 22, p = 0.013). Among 38 infants who completed a 3 month vitamin D supplementation intervention, provision of 400 IU/day of vitamin D increased final 25(OH)D to a higher level in non-Hispanic Caucasian compared to Hispanic infants. There was no significant relationship between cord serum 25(OH)D and BMC or BMD in the first week of life (n = 49) or after 3 months of vitamin D supplementation.

CONCLUSION:

Low cord 25(OH)D levels are seen in Hispanic infants, but their functional significance is uncertain related to bone health in a southern US setting. Daily vitamin D intake of 400 IU during the first months of life appears adequate to increase serum 25(OH)D and support BMC increases despite low initial 25(OH)D levels in some infants.

TRIAL REGISTRATION:

ClincalTrials.gov NCT00697294.

PMID:
22248486
PMCID:
PMC3271033
DOI:
10.1186/1471-2431-12-6
[Indexed for MEDLINE]
Free PMC Article
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