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Clin Sci (Lond). 2012 May;122(9):397-407. doi: 10.1042/CS20110506.

Endothelial cells and magnesium: implications in atherosclerosis.

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1
Dipartimento di Scienze Cliniche L. Sacco, Università di Milano, Via G.B. Grassi 74, Milano, Italy. jeanette.maier@unimi.it

Abstract

There is no doubt that the functional and structural integrity of the endothelium is critical in maintaining vascular homoeostasis and in preventing atherosclerosis. In the light of epidemiological and experimental studies, magnesium deficiency is emerging as an inducer of endothelial dysfunction. In particular, data on the effects of low extracellular magnesium on cultured endothelial cells reinforce the idea that correcting magnesium homoeostasis might be a helpful and inexpensive intervention to prevent and treat endothelial dysfunction and, consequently, atherosclerosis.

PMID:
22248353
DOI:
10.1042/CS20110506
[Indexed for MEDLINE]
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