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Annu Rev Med. 2012;63:405-19. doi: 10.1146/annurev-med-061610-154046.

Traumatic brain injury and its neuropsychiatric sequelae in war veterans.

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Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota 55417, USA.


The post-September 11, 2001 wars in and around Afghanistan and Iraq have increased awareness of traumatic brain injury (TBI), particularly blast-induced mild TBI. This article provides an overview of TBI and its neuropsychiatric sequelae in U.S. war veterans who participated in the current operations in and around Afghanistan and Iraq, with particular emphasis on blast-related mild TBI. Psychiatric disorders, particularly posttraumatic stress disorder, pain, and sensory impairments are prevalent in war veterans with TBI. Research is needed to more definitively characterize the epidemiology of TBI-related functional difficulties, the effects of blasts compared with other mechanisms of injury, recovery trajectories, and treatment outcomes in this population.

[Indexed for MEDLINE]

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