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World J Biol Psychiatry. 2013 Sep;14(7):478-89. doi: 10.3109/15622975.2011.601759. Epub 2012 Jan 17.

Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects.

Author information

1
Department of Chemical Engineering and Biotechnology, University of Cambridge , Cambridge , UK.

Abstract

OBJECTIVES:

To identify a molecular profile for schizophrenia using post-mortem pituitaries from schizophrenia and control subjects.

METHODS:

Molecular profiling analysis of pituitaries from schizophrenia (n = 14) and control (n = 15) subjects was carried out using a combination of liquid chromatography tandem mass spectrometry (LC-MS(E)), multiplex analyte profiling (MAP), two-dimensional difference gel electrophoresis (2D-DIGE) and Western blot analysis.

RESULTS:

This led to identification of differentially expressed molecules in schizophrenia patients including hypothalamic-pituitary-adrenal axis-associated constituents such as cortisol, pro-adrenocorticotropic hormone, arginine vasopressin precursor, agouti-related protein, growth hormone, prolactin and secretagogin, as well as molecules associated with lipid transport and metabolism such as apolipoproteins A1, A2, C3 and H. Altered levels of secretagogin in serum from a cohort of living first onset schizophrenia patients were also detected, suggesting disease association and illustrating the potential for translating some components of this molecular profile to serum-based assays.

CONCLUSIONS:

Future studies on the molecules identified here may lead to new insights into schizophrenia pathophysiology and pave the way for translation of novel diagnostics for use in a clinical setting.

PMID:
22248022
DOI:
10.3109/15622975.2011.601759
[Indexed for MEDLINE]

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