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Sensors (Basel). 2011;11(12):11036-55. doi: 10.3390/s111211036. Epub 2011 Nov 28.

Overview of stabilizing ligands for biocompatible quantum dot nanocrystals.

Author information

1
Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA. yanjiez@iastate.edu

Abstract

Luminescent colloidal quantum dots (QDs) possess numerous advantages as fluorophores in biological applications. However, a principal challenge is how to retain the desirable optical properties of quantum dots in aqueous media while maintaining biocompatibility. Because QD photophysical properties are directly related to surface states, it is critical to control the surface chemistry that renders QDs biocompatible while maintaining electronic passivation. For more than a decade, investigators have used diverse strategies for altering the QD surface. This review summarizes the most successful approaches for preparing biocompatible QDs using various chemical ligands.

KEYWORDS:

biocompatible; ligand; quantum dots

PMID:
22247651
PMCID:
PMC3251968
DOI:
10.3390/s111211036
[Indexed for MEDLINE]
Free PMC Article
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