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Ann Rheum Dis. 2012 May;71(5):718-21. doi: 10.1136/annrheumdis-2011-200631. Epub 2012 Jan 12.

Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry.

Collaborators (698)

Stetter M, Lackner K, Tomi N, Hafner F, Brodmann M, Kuen-Spiegel M, Kolle H, Raffier B, Hamberger N, Metz S, Siebel C, Trummer M, Thonhofer R, Illmer X, Trautinger F, Schmidt P, Rintelen B, Sautner J, Willfort-Ehringer A, Margeta C, Monshi B, Pirkhammer D, Richter L, Holzer G, Minmair G, Broll H, Takacs M, Hirschl M, Mesaric P, Feldmann R, Semmelweis K, Hundstorfer M, Reinhart V, Maurer B, Verner D, Distler O, Schmidt-Bosshard R, Bohmova J, Prochazkova L, Nemec P, Fojtik Z, Soukup T, Smrzova A, Suchy D, Zemanova I, Becvar R, Gawlik A, Koch M, Rauen T, Voss B, Kurthen R, Unholzer A, Starz H, Welzel J, Plaumann K, Merk B, Bloching HH, Moosig F, Frey P, Kahl S, Schleenbecker H, Storck-Mueller K, Schwarting A, Hazenbiller A, Nichelmann V, Flaig W, Rumbaur C, Boesenberg I, Schmeiser T, Marx J, Mayer L, Stein T, Ochs W, Rasche C, Worm M, Riemekasten G, Deuschle K, Becker M, Kleiner HJ, Schulze K, Tiggers C, Peters J, Kirschke J, Schaefer C, Monshausen M, Mengden T, Sadeghlar F, Seidel M, Hillebrecht C, Andresen J, Reemtsen R, Stoeckl F, Sperling S, Podda M, Wagner N, Guenzel J, Wuerzburg I, Luethke K, Enderlein M, Kayser M, Gerber A, Haust M, Hoff NP, Mota R, Akanay-Diesel S, Jahnke K, Mettler S, Toeller S, Zwenger S, Klein E, Hahn K, Beyer C, Distler J, Katzemich A, Erfurt-berge C, Sticherling M, Schuch F, Rapp P, Mitchell A, Freundlieb C, Rushentsova U, Himsel A, Henkemeier U, Eilbacher P, Ullrich-Guenther C, Neul S, Oelsner M, Hermanns G, Fiene M, Gause A, Mensing C, Klings D, Mensing H, Messall J, Zuper R, May D, Bruckner L, Sheikh N, Aries P, Kirchberg S, Funkert A, Blank N, Lupaschko S, Schwuerzer-Voit M, Meier L, Herr U, Meier U, Neek G, Wernitzsch H, Pfoehler C, Assmann G, Vosswinkel J, Krog B, Wollersdorfer E, Oltmann-Schroeder J, Zeuner R, Uhlig S, Barth S, Huegel R, Glaeser R, Rabe B, Schuster J, Scholz J, Kremer K, Robakidze-Torbahn M, Moinzadeh P, Mittag M, Dohse A, Muhlack A, Schultz L, Schult S, Frambach Y, Kettenbach A, Fell I, Schweda K, Steinbrink K, Podobinska M, Harmuth W, Nielen C, Kaczmarczyk A, Kellner C, von Oelhafen J, von Bildering PB, Kunze S, Niedermeier A, Messer G, Sardy M, Bekou V, Belloni B, Huettig B, Ziai M, Hein R, Hallecker A, Gaubitz M, Hallermann C, Schmidt K, Herrgott I, Hildebrandt B, Eiden E, Guertler I, Gernot Scheibl E, Brand H, Kaeding U, Weiss E, Reischel N, Kern S, Baumann C, Hellmich B, Loeffler C, Pflugfelder J, Karaenke P, Ruchenburg J, Blume J, Zabel M, Deppermann N, Chromik S, Metzler C, Krupp E, Rumpel H, Krause Rostock JO, Kneitz C, Federow I, Schneider K, Semmler M, Hapke S, Barnd A, Linke M, Kampe-Juzak E, Knoebel K, Niefanger K, Wilhelm HU, Lauterwein B, Fierlbeck G, Schanz S, Pfeiffer C, Hassel R, Wahn H, Schildt K, von Elling A, Boro D, Ebel J, Ahmadi K, Moritz D, Dietl S, Dyballa J, Alsheimer B, Schuetz N, Schuart T, Mueglich C, Tony HP, Marina P, Deininger F, Hartmann F, Olsen AB, Sondergaard KH, Naderi Y, Iversen LV, Karlsmark T, Knudsen JB, Gil JG, Lopez JC, Tasende JA, Gonzales MF, Sandoval AA, del Carmen Torres Martin M, Corteguera M, Barca BA, Montes IC, de la Torre RG, Victoria Egurbide M, Pros A, Munoz J, Simeon CP, Espinosa G, Espinposa G, Rodriguez MA, Castellvi I, Mascaro JM, Bellido D, Manzanedo VS, Huertas MP, Sanchez MD, Trenado MS, Garcia PV, Gines Martinez F, Angeles Aquirre M, del Rio AH, Vazquez JL, Coleman JV, Lopez MR, Sanchez PS, Aizpuru EM, Mateo FJ, Callejas JL, Ortego N, Castellvi I, Santo MP, Rubio M, Martin I, Cruz A, Crespo M, Ramos PC, Fernandez AS, Filloy JA, Rodriguez TR, Marhuenda AR, Blanco JJ, Hernan MG, Mendoza AZ, De la Puente C, Rabaneda EV, de Vicuna RG, del Mar Ripoll Macias M, del la Pena Lefebvre PG, de Ramon E, Camps MT, Fernandez C, Miguelez R, Uson J, Delgado EG, Villaverde V, Maceiras F, Cruz J, Mosquera JA, Mera A, Pampin EP, Blanco JS, Maneiro JR, Diaz JJ, Losada L, Caamano M, Fernandez S, Insua SA, Laurin CU, Sanchez J, Fernandez NC, Becerra ND, Garcia A, Nicolas GM, del Carmen Ortega de la O M, Rueda A, Calvo J, Roman Ivorra J, Sancho Alegre JJ, Barbado J, Montes J, Saez L, Kaarto A, Makinen H, Madaule S, Dadban A, Lok C, Ferrandiz D, Moiton MP, Magy-Bertrand N, Taieb A, Droitcourt C, Belin E, Balquiere S, Prey S, Boulon C, Constans J, Richez C, Sassolas B, Misery L, Greco M, collet E, Berthier S, Leguy-Seguin V, Imbert B, Carpentier P, Blaise S, Maillard H, Beneton N, Launay D, Hachulla E, Woijtasik G, Charlanne H, Lambert M, Jourdain N, Hatron PY, Morell S, Spars A, Couraud A, Doeffel-hantz V, Fauchais AL, Vidal E, Goudran G, Bezanahary H, Boussely N, Manea P, Dumonteil S, Loustaud-ratti V, Hot A, Coppere B, Desmurs-Clavel H, Ninet J, Girard-Madoux MH, Granel B, Keynote A, Khau van Kien A, Rullier P, Le Quellec A, Riviere S, Bessis D, Cohen JD, Farcas C, Granel-brocard F, Agard C, Durant C, Fuzibet JG, Queyrel V, Berezne A, Guillevin L, Mouthon L, Frances C, Toledano C, Cabane J, Tiev K, Farge D, Keshtmand H, Lazareth I, Priollet P, Michon-Pasturel U, Wipff J, Assous N, Cartry O, Kostrzwewa E, Doutre MS, Blum L, Reguiai Z, Letremy A, Perlat A, Cazalets-lacoste C, Decaux O, Jego P, Duval-modeste AB, Deboves O, Sordet C, Chatelus E, Chiffot H, Sibillia J, Couret B, Moulis G, Sailler L, Adoue D, Gaches F, Diot E, Skowron F, Zenone T, Quemeneur T, Kyndt X, Wahl D, Zuily S, Moline T, Bravetti V, Galanopoulos N, Vasilopoulos D, Vlachoyannopoulos P, Kritikos I, Tsifetaki N, Koutroumbas A, Garyfallos A, Athanassiou P, Aslanidis S, Kamali S, Dimitroulas T, Galanopoulo V, Elezoglou A, Grier A, Murray M, O'Rourke M, Gabrielli A, Lapadula G, Serafino L, Terlizzi N, Bellissimo S, Stisi S, Malavolta N, Airo P, Vacca A, Battaglia E, Foti R, Mazzuca S, Bortoluzzi A, Trotta F, Galluccio F, Marucci A, Cantatore F, Bucci R, Puppo F, De Angeli R, Grassi W, Cipriani P, Mazzone A, Faggioli P, Severino A, Scorza R, Belloli L, Ughi N, Antivalle M, Del Papa N, Maglione W, Zeni S, Ferri C, Colaci M, Varcasia G, Cuomo G, Cozzi F, Triolo G, Gatti S, Montecucco CM, Doveri M, Nigro A, Olivieri I, Bajocchi G, Rosato E, Salsano F, Faustini F, Ferraccioli G, Colonna L, Pallotta S, Riccieri V, Mussi A, Bellisai F, Galeazzi M, Fusaro E, Saracco M, Pellerito R, Masolini P, De Vita S, Lombardi S, Lunardi C, Moolenburgh JD, Heurkens AH, Voskuyl A, Hak AE, Stroes ES, Remans J, Gerdes V, van Woerkom JM, de Long AJ, Kaasjager HA, Visser H, Janssen M, Van Guldener C, Van Neer F, Vos P, Peters AJ, Hulsmans H, Ronday K, Goekoop R, Ewals J, Valentijn R, de Bois M, Westedt ML, Siewertsz van Reesema D, Knifjj-Dutmer E, Stolk JN, Willems H, Kuiper-geertsma DG, Baudaoin P, Fretter P, Westra R, Sonnaville PB, SMIT A, Bootsma H, Brouwer L, Bijl M, Molders N, Lebrun C, van der Veen MJ, Noordzij M, Houben H, Landewe RM, Vercoutere W, Jahangier de Veen ZN, Zijlstra TR, Ubels F, Bruyn G, Jansen P, Schuerwegh A, Huizinga TW, Paassen P, Hurkens T, Geurts M, van den Hoogen F, Vonk M, Jacobs PJ, Groenendael JH, Seys P, van Zeben D, van Paassen H, Groenendael J, Han KH, Wlarvens M, van Hagen M, van Daele P, Dolhain R, Gerards AH, van der Lubbe P, Kanter MD, Muller WH, Ton E, Van Krugten M, van Gameren I, Lanting P, den Hengst C, Gjessdal CG, Hjertaker SL, Madland TM, Bendvold A, Bitter H, Hoffmann-Vold AM, Midtvedt O, Bakland G, Aslkaksen HK, Seip M, Kalstad S, Koldingsnes W, Grandauent B, Nordvag BY, Stran EK, Skomsvoll J, Andersen M, Thomsen RS, Pedersen T, Bakkeheim V, Cordeiro A, Alves J, Oliveira S, Coelho P, Resende C, Ponte C, Almeida I, Silva I, Santos C, Camara I, Costa J, Hellstrom H, Mohammad A, Lind I, Lind K, Bracin T, Liljequist E, Vingren T, Ostenson A, Hermansson E, Thorsson C, Soderlin M, Nordin A, Waldheim E, Vengemyr K, Albertsson K, Karlsson ML, Rydvald Y, Rizk M, Dolnicar AS, Lukac J, James J, Mchugh N, Cole S, Brown S, Hamilton A, Faizal A, Hall F, Murphy K, Skingle S, Harris H, Madhok F, Hampson R, Baguley E, Ogunbambi G O, Lamb J, Anderson M, Moots R, White-Alao B, Morrison C, Dobson J, Gordon P, Salerno R, Denton C, Parker L, Ochiel R, Vincent R, Zimba S, Ngcozana T, Xu Y, D'Cruz D, Choong LM, Herrick A, Wragg E, Manning J, Moore T, Kelsey C, Chakravarty K, Skyes H, Athiveer P.

Abstract

OBJECTIVES:

The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).

METHODS:

The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.

RESULTS:

Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.

CONCLUSIONS:

This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies.

PMID:
22247218
PMCID:
PMC3329234
DOI:
10.1136/annrheumdis-2011-200631
[Indexed for MEDLINE]
Free PMC Article

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