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EMBO J. 2012 Mar 21;31(6):1350-63. doi: 10.1038/emboj.2011.494. Epub 2012 Jan 13.

Axonal transcription factors signal retrogradely in lesioned peripheral nerve.

Author information

1
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin α5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus.

PMID:
22246183
PMCID:
PMC3321171
DOI:
10.1038/emboj.2011.494
[Indexed for MEDLINE]
Free PMC Article

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