Format

Send to

Choose Destination
J Neuroimmunol. 2012 Mar;244(1-2):103-6. doi: 10.1016/j.jneuroim.2011.12.023. Epub 2012 Jan 14.

Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis.

Author information

1
Center for Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d' Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.

Abstract

Contactin-2 was recently identified as an autoantigen targeted by T-cells and autoantibodies in multiple sclerosis (MS). Here we analyzed the frequency of antibodies to contactin-2 (contactin-2-ab) by a cell-based assay in the serum from 105 MS patients and at least 5 years of follow-up (19 clinically isolated syndromes, 51 relapsing-remitting, 20 secondary-progressive, and 15 primary-progressive). Contactin-2-ab were detected in 4 (7.8%) relapsing-remitting patients. Clinical and magnetic resonance imaging characteristics were not significantly different from the rest of relapsing-remitting patients. In conclusion, contactin-2-ab are identified in a minority of MS patients but their presence is not associated with a particular clinical-radiological profile.

PMID:
22245283
PMCID:
PMC4800093
DOI:
10.1016/j.jneuroim.2011.12.023
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center