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Immunol Allergy Clin North Am. 2012 Feb;32(1):11-33. doi: 10.1016/j.iac.2011.12.003.

Determinants of food allergy.

Author information

1
Division of Allergy and Immunology, Department of Pediatrics, The Jaffe Food Allergy Institute, Mount Sinai School of Medicine, Anbg 17-40, One Gustave L Levy Place, New York, NY 10029, USA.

Abstract

Food allergy is an emerging epidemic in the United States and the Western world. The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction of thousands of proteins and other molecules is responsible for inducing food allergy. In this review, the authors present 3 examples of food allergies with disparate clinical presentations: peanut, soy, and mammalian meat. The potential relationships between allergen structure and function, emphasizing the importance of cross-reactive determinants, immunoglobulin E antibodies to the oligosaccharides, and the immune responses induced in humans are discussed.

PMID:
22244230
PMCID:
PMC3312744
DOI:
10.1016/j.iac.2011.12.003
[Indexed for MEDLINE]
Free PMC Article

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