Format

Send to

Choose Destination
N S W Public Health Bull. 2011 Dec;22(11-12):224-9. doi: 10.1071/NB11023.

The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules.

Author information

1
National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead. HelenQ@chw.edu.au

Abstract

The pertussis epidemic experienced in NSW in 2008-2009 was likely to be in part due to changes in diagnostic practice since 2007, which amplified disease notifications. We used population-based seroepidemiology as a less biased means of interpreting age-specific pertussis infection patterns in NSW from three serosurveys undertaken in 1997-98 (during an epidemic), 2002 (post-epidemic) and 2007 (inter-epidemic), using a standardised pertussis toxin IgG enzyme-linked immunosorbent assay (ELISA). There was a decrease in the proportion of high anti-pertussis toxin IgG titres (>62.5ELISAUnits/mL) across all age groups in the 2007 serosurvey compared to the previous two serosurveys. In the 2007 serosurvey, the proportion of undetectable (<5ELISAUnits/mL) anti-pertussis toxin IgG titres increased in many age groups. The seroepidemiological profiles of the three serosurveys demonstrate fluctuating immunity profiles related to changes in vaccination schedules.

PMID:
22243639
DOI:
10.1071/NB11023
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for CSIRO Icon for Sax Institute
Loading ...
Support Center