This article describes a design of physiological signal storage format and transfer protocol for the tele-medical system between home and community. The protocol is based on ASCII character, with frames as its basic structure. There are two kinds of frames: control frames and data frames. Control frames can start and stop data transfer, confirm the order, and ask for start. There are seven kinds of data frames, according to the different data types. Data is transferred in data frames. The protocol described in this article is simple and extensible. The design target has been accomplished in real system.