Format

Send to

Choose Destination
See comment in PubMed Commons below
Nihon Rinsho. 2011 Dec;69(12):2167-71.

[Stem cell therapy for intractable skin diseases].

[Article in Japanese]

Author information

1
Stem Cell Therapy Science, Graduate School of Medicine, Osaka University.

Abstract

Previous studies have shown that bone marrow provides fibroblastic-like cells in the dermis and keratinocytes in the epithelia. Subsequent studies by us and other groups have demonstrated that both embryonic and postnatal transplantation of bone marrow cells in model mice of epidermolysis bullosa (EB), a heritable blistering skin disease due to genetic mutation of cutaneous basement membrane components, promote skin wound healing and correct the intrinsic basement membrane defect. We also reported that the source of the epithelial progenitors in mouse bone marrow was the nonhematopoietic, platelet-derived growth factor receptoralpha (PDGFRalpha)-positive bone marrow mesenchymal stem cell (MSC) population. In this review, recent progress as well as future perspectives of bone marrow MSC therapy for EB will be summarized.

PMID:
22242315
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center