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PLoS Pathog. 2011 Dec;7(12):e1002344. doi: 10.1371/journal.ppat.1002344. Epub 2011 Dec 29.

Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?

Author information

1
Mayo Vaccine Research Group, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota, United States of America. Poland.gregory@mayo.edu

Abstract

As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a current major barrier in vaccinology-that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper-variable viruses. While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate.

PMID:
22241978
PMCID:
PMC3248557
DOI:
10.1371/journal.ppat.1002344
[Indexed for MEDLINE]
Free PMC Article

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