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Nat Rev Immunol. 2012 Jan 13;12(2):114-24. doi: 10.1038/nri3150.

Early immune events in the induction of allergic contact dermatitis.

Author information

1
Department of Dermatology, Center for Immunology, University of Minnesota, MBB 3-146, 2101 6th St. SE, Minneapolis, Minnesota 55414, USA. dankaplan@umn.edu

Abstract

The skin is a barrier site that is exposed to a wide variety of potential pathogens. As in other organs, pathogens that invade the skin are recognized by pattern-recognition receptors (PRRs). Recently, it has been recognized that PRRs are also engaged by chemical contact allergens and, in susceptible individuals, this elicits an inappropriate immune response that results in allergic contact dermatitis. In this Review, we focus on how contact allergens promote inflammation by activating the innate immune system. We also examine how innate immune cells in the skin, including mast cells and dendritic cells, cooperate with each other and with T cells and keratinocytes to initiate and drive early responses to contact allergens.

PMID:
22240625
PMCID:
PMC3578582
DOI:
10.1038/nri3150
[Indexed for MEDLINE]
Free PMC Article

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