Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Immunol. 2012 Apr;24(2):191-5. doi: 10.1016/j.coi.2011.12.004. Epub 2012 Jan 10.

Transcriptional mechanisms that regulate T helper 1 cell differentiation.

Author information

1
Department of Immunology, University of Washington, Seattle, WA 98195, USA.

Abstract

Recent research has made great strides in uncovering the mechanisms by which the T helper 1 (Th1) cell gene expression program is established. In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have started to address their contributions to the epigenetic states in Th1 cells. Additionally, new findings have provided information about how the co-expression of T helper cell lineage-defining transcription factors impacts the phenotype of the cell. In this review, we will briefly highlight the research from the last few years examining the epigenetic states in T helper cells and the mechanisms by which they are established. We will then discuss how this new information contributes to our understanding of the flexibility of T helper cell genetic programs.

PMID:
22240120
PMCID:
PMC3319510
DOI:
10.1016/j.coi.2011.12.004
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center