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Phys Med Rehabil Clin N Am. 2012 Feb;23(1):201-7, xiii. doi: 10.1016/j.pmr.2011.11.012. Epub 2011 Dec 13.

Aging of human muscle: understanding sarcopenia at the single muscle cell level.

Author information

1
Department of Physical Medicine and Rehabilitation, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA. walter.frontera@upr.edu

Abstract

The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes in elderly men and women. A detailed understanding of this problem in humans can be enhanced by the use of experiments with single muscle fibers. It is likely that both muscle atrophy and a decrease in muscle-fiber quality contribute to muscle dysfunction among the elderly. A better understanding of sarcopenia at the single-fiber level may lead to the design of more effective rehabilitative interventions.

PMID:
22239884
PMCID:
PMC3258429
DOI:
10.1016/j.pmr.2011.11.012
[Indexed for MEDLINE]
Free PMC Article

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