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Phys Med Rehabil Clin N Am. 2012 Feb;23(1):1-10, ix. doi: 10.1016/j.pmr.2011.11.004. Epub 2011 Dec 14.

Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.

Author information

1
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA. hedderic@ohsu.edu

Abstract

Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

PMID:
22239869
PMCID:
PMC3561672
DOI:
10.1016/j.pmr.2011.11.004
[Indexed for MEDLINE]
Free PMC Article

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