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J Am Chem Soc. 2012 Jan 18;134(2):751-3. doi: 10.1021/ja2076873. Epub 2011 Dec 29.

Membrane assembly driven by a biomimetic coupling reaction.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide-alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precursors. The substitution of efficient synthetic reactions for key biochemical processes may offer a general route toward synthetic biological systems.

PMID:
22239722
PMCID:
PMC3262119
DOI:
10.1021/ja2076873
[Indexed for MEDLINE]
Free PMC Article

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