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PLoS One. 2012;7(1):e29459. doi: 10.1371/journal.pone.0029459. Epub 2012 Jan 6.

Family history and breast cancer hormone receptor status in a Spanish cohort.

Author information

1
Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America. xuejuanj@usc.edu

Abstract

BACKGROUND:

Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.

MATERIALS AND METHODS:

A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.

RESULTS:

Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ER-&PR-. Women with a family history of breast cancer were more likely to have ER-&PR- tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91-2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34-5.81).

CONCLUSIONS:

An increased proportion of ER-&PR- breast cancer was observed among younger Spanish women with a family history of the disease.

PMID:
22238615
PMCID:
PMC3253097
DOI:
10.1371/journal.pone.0029459
[Indexed for MEDLINE]
Free PMC Article

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