Format

Send to

Choose Destination
Bioinformatics. 2012 Mar 1;28(5):747-9. doi: 10.1093/bioinformatics/bts010. Epub 2012 Jan 11.

IMID: integrated molecular interaction database.

Author information

1
Department of Statistics, Florida State University, Tallahassee, FL 32306, USA.

Abstract

MOTIVATION:

Molecular interaction information, such as protein-protein interactions and protein-small molecule interactions, is indispensable for understanding the mechanism of biological processes and discovering treatments for diseases. Many databases have been built by manual annotation of literature to organize such information into structured form. However, most databases focus on only one type of interactions, which are often not well annotated and integrated with related functional information.

RESULTS:

In this study, we integrate molecular interaction information from literature by automatic information extraction and from manually annotated databases. We further integrate the relationships between protein/gene and other bio-entity terms including gene ontology terms, pathways, species and diseases to build an integrated molecular interaction database (IMID). Interactions can be selected by their associated probabilities. IMID allows complex and versatile queries for context-specific molecular interactions, which are not available currently in other molecular interaction databases.

AVAILABILITY:

The database is located at www.integrativebiology.org.

PMID:
22238258
PMCID:
PMC3289914
DOI:
10.1093/bioinformatics/bts010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center