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Lab Chip. 2012 Feb 21;12(4):696-701. doi: 10.1039/c2lc20951a. Epub 2012 Jan 12.

Education: a microfluidic platform for university-level analytical chemistry laboratories.

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Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.


We demonstrate continuous flow acid-base titration reactions as an educational microfluidic platform for undergraduate and graduate analytical chemistry courses. A series of equations were developed for controlling and predicting the results of acid-base neutralisation reactions conducted in a microfluidic format, including the combinations of (i) a strong base and a strong acid, (ii) a strong base and a weak acid, and (iii) a strong base and a multiprotic acid. Microfluidic titrations yielded excellent repeatability. The small experimental footprint is advantageous in crowded teaching laboratories, and it offers limited waste and exposure to potentially hazardous acids and bases. This platform will help promote the utilisation of microfluidics at an earlier stage of students' careers.

[Indexed for MEDLINE]

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